Overview

Since the early 1980's, nucleoside analogues have been the cornerstone of antiviral chemotherapy. The prevalence of Herpes, Hepatitis B & C and HIV infections will ensure that these compounds remain important agents in antiviral chemotherapy. The success of the early agents, such as acyclovir, and the toxicity and metabolic instability of many nucleoside analogues, is driving the design, synthesis and evaluation of new nucleoside analogues, with much attention turning to nucleosides containing non-natural sugar analogues. This book focuses on the development of these non-natural sugar containing agents, and covers their design, synthesis and important antiviral properties along with comparisons to the related normal nucleosides. The authors' critical evaluation of the current state of research gives a true perspective of the utility of these classes of compounds.

Full Product Details

Author:   L. Agrofoglio ,  S.R. Challand
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   1998 ed.
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   1.610kg
ISBN:  

9780751404340

ISBN 10:   0751404349
Pages:   383
Publication Date:   31 October 1998
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

General introduction.- References.- 1 The chemistry of acyclic nucleosides.- 1.1 Introduction.- 1.2 Acyclovir and its derivatives.- 1.3 Ganciclovir (DHPG) and its derivatives.- 1.4 Acyclic nucleoside phosphonate analogues.- 1.5 Seconucleosides and their derivatives.- 1.6 Miscellaneous acyclic nucleosides.- References.- 2 Biological activity of acyclic nucleosides.- 2.1 Introduction.- 2.2 Acyclovir and its prodrugs.- 2.3 Ganciclovir and its prodrugs.- 2.4 Penciclovir and famciclovir.- 2.5 Phosphonylmethoxyalkylpurines.- 2.6 HEPT.- 2.7 Allenes.- 2.8 Conclusion.- References.- 3 The chemistry of carbocyclic nucleosides.- 3.1 Introduction.- 3.2 Coupling procedures for introducing the heterocycle moiety.- 3.3 Synthesis of functionalized cyclopentylamines with ribo-, arabino-, or xylo-configurations.- 3.4 Fluorinated carbocyclic nucleoside analogues.- 3.5 Carbocycles substituted by other functional groups.- 3.6 Cyclobutyl analogues of nucleosides.- 3.7 Synthesis of cyclopropyl analogues of nucleosides.- 3.8 Cyclohexyl nucleosides.- References.- 4 Biological activity of carbocyclic nucleosides.- 4.1 Introduction.- 4.2 Inhibitors of AdoHcy hydrolase (SAH).- 4.3 Inhibitors of viral DNA replication.- 4.4 Reverse transcriptase inhibitors; carbovir and its prodrugs.- 4.5 Cyclopropyl- or cyclohexyl- analogues of nucleosides.- 4.6 Conclusion.- References.- 5 The chemistry of L-nucleosides.- 5.1 Introduction.- 5.2 Synthesis of L-nucleosides.- 5.3 Synthesis of iso-L-nucleosides.- 5.4 Summary.- References.- 6 Anti-viral activities of L-nucleosides.- 6.1 Introduction.- 6.2 Anti-viral activity of ?-L-ddNs.- 6.3 Activities of ?-L-oxothiolanyl and dioxolanyl nucleosides.- 6.4 Activity of ?-L-fluorinated nucleosides.- 6.5 Activity of miscellaneous ?-L-nucleosides.- 6.6 Conclusion.-References.- Appendix A Nomenclature of nucleosides.- Appendix B Abbreviations in widespread use.- Appendix C Glossary of terms used.- Appendix D Acknowledgements.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions