Overview

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.

Full Product Details

Author:   Oussama Abla ,  Francesco Lo Coco ,  Miguel A. Sanz
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   Softcover reprint of the original 1st ed. 2018
Weight:   0.750kg
ISBN:  

9783030097134

ISBN 10:   3030097137
Pages:   274
Publication Date:   01 February 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

History of APL.- Molecular Targets of Treatment in APL.- The Leukemic Stem Cell.- The Molecular Genetics of APL.- APL Coagulopathy.- Early Death in APL.- Prognostic Factors in APL.- First-line therapy for APL: Chemotherapy-based approach.- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach.- Cure of APL without Chemotherapy.- Minimal Residual Disease in APL.- Treatment of refractory and relapsed APL.- Hematopoietic Stem Cell Transplantation in APL.- APL in Children.- Management of APL in the Elderly.- Special Situations in APL.- APL in Developing Countries: A Chemotherapy-Based Approach.- APL in Developing Countries: ATO based Approach.- Therapy-Related APL.- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes.- Management of Treatment-Related Complications in APL.

Reviews

“This is a clinical guide to acute promyelocytic leukemia or APL, and it is the first book dedicated entirely to APL. Starting with an engaging historical account, the book provides a comprehensive overview of the clinical and basic aspects of APL, once regarded as the most fatal type of acute myeloid leukemia, but now considered the most curable. … general practitioners and trainees also will find this book worth exploring … .” (Ravi Salgia, Doody's Book Reviews, January 04, 2019)

This is a clinical guide to acute promyelocytic leukemia or APL, and it is the first book dedicated entirely to APL. Starting with an engaging historical account, the book provides a comprehensive overview of the clinical and basic aspects of APL, once regarded as the most fatal type of acute myeloid leukemia, but now considered the most curable. ... general practitioners and trainees also will find this book worth exploring ... . (Ravi Salgia, Doody's Book Reviews, January 04, 2019)

Author Information

Oussama Abla, MD The Hospital for Sick Children and University of Toronto Division of Hematology/Oncology Toronto, ON Canada   Francesco Lo-Coco, MD Professor of Hematology University of Tor Vergata Rome Italy   Miguel A. Sanz, MD Centro de Investigación Biomédica en Red de Cáncer Madrid Spain

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