Overview

The field of research in 5-hydroxytryptamine has exploded into furious activity over the past decade and nowhere have the implications been more far reaching than in psychiatry. Thanks largely to the introduction of radioligand binding techniques, a bewildering variety of 5-hydroxytryptamine receptors has been revealed, and powerful new families of centrally-active drugs have emerged. The importance of these new discoveries for psychiatric practice can hardly be exaggerated. To mention but one example, our understanding, and with it the treatment, of obsessive-compulsive disorder has been transformed in a very few years. The excitement continues, and almost daily, some important new insight, usually drug led, alters our whole perception of psychiatric illness. Due to this activity, the CINP chose 5-hydroxytryptamine and Psychiatry as the topic for its first President's Workshop. The CINP is an international neuropharmacological organization renowned for its massive, comprehensive, and prestigious biennial congress. It recently decided to complement these with a different type of gathering, a small brain-storming meeting, dominated by a free-flowing discussion. The record of this first President's Workshop is recorded here. The contributors were all hand-picked, and are active researchers with a distinguished track record. They have all contributed substantially to the burgeoning 5-hydroxytryptamine field. The free-ranging style of this volume and the many good ideas presented cannot fail to be of major interest to all who wish to keep abreast of this rapidly moving area of research.

Full Product Details

Author:   Merton Sandler (Professor of Chemical Pathology, Professor of Chemical Pathology, Queen Charlotte's and Chelsea Hospital) ,  Alec Coppen (Director, Director, MRC Neuropsychiatry Laboratory) ,  Sara Harnett ,  S. Harnett
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 16.30cm , Height: 2.70cm , Length: 24.10cm
Weight:   0.720kg
ISBN:  

9780192620118

ISBN 10:   0192620118
Pages:   364
Publication Date:   21 February 1991
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

An overview of a 5-hydroxytryptamine receptor families, S.J. Peroutka and A.W. Schmidt; an overview of serotonin neuroanatomy, D.L. Murphy; milacemide - a neuropsychotropic glycine prodrug that potentiates serotonergic activity, M.B.H. Youdim; the inactive enantiomer of a noradrenaline uptake blocker reduces 5-HT synthesis, P.C. Waldemeier and L. Maitre; platelet serotonin studies in affective disorders - evidence for a serotonergic abnormality?, H.Y. Meltzer and R.C. Arora; the role of 5-HT in migraine - disentangling the links with depression, V. Glover et al; the acute effect of monoamine oxidase inhibitors on serotonin conversion to melatonin, G.F. Oxenkrug; stimulation of rat pineal melatonin synthesis by a single electroconvulsive shock - chronobiological effect of antidepressant therapy?, G.F. Oxenkrug et al; cAMP-dependent binding proteins and endogenous phosphorylation after antidepressant treatment, G. Racagni et al; abnormal 5-HT neuroendocrine function in depression - association or artefact?, P.J. Cowen and I.M. Anderson; experimental tests of the 5-HT imbalance theory of affective disturbance, J. Deakin; antidepressant efficacy of 5-HT1A partial agonist drugs, D.S. Robinson; neuroendocrine serotonergic challenges in clinical research, J.J. Lopez-Ibor Jr et al; serotonin in anxiety - evidence from animal models, M. Briley and P Chopin; anxiogenic effect of 5-HT1C agonist m - chlorophenylpiperazine, G. Curzon et al; does 5-hydroxtryptamine have a role in anxiety and the action of anxiolytics?, M. Palfreyman and J.H. Kehne; serotonin in obsessive-compulsive disorder - a casual connection or more monomania about a major monoamine?, T.R. Insel; monoamines, glucose metabolism, and impulse control, M. Linnoila; 5-Hydroxtryptamine in the control of feeding and its possible implications for appetite disturbance, G. Curzon; d-Fenfluramine and animal models of eating disorders, B. Guardiola-Lemaitre; disturbance of the 5-hydroxtryptamine metabolism in ageing and in Alzheimer's and vascular dementias, C.G. Gottfries; 5-HT3 receptor antagonists and their potential in psychiatric disorders, M.G. Palfreyman et al; a typical antipsychotic drugs - the 5HT2/DA2 ratio, H.Y. Meltzer.

Reviews

`This is a pleasure to read. The book is well indexed and referenced and each chapter is followed by excellent summaries of the discussions that followed each presentation. This is a `must' for all medical libraries and will be invaluable for any clinical or basic psychopharmacologist who wishes to get up to date with this fascinating area of neurobiology.' Human Psychopharmacology

'This is a pleasure to read. The book is well indexed and referenced and each chapter is followed by excellent summaries of the discussions that followed each presentation. This is a 'must' for all medical libraries and will be invaluable for any clinical or basic psychopharmacologist who wishes to get up to date with this fascinating area of neurobiology.' Human Psychopharmacology

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