Overview

This book examines the principles underlying genetic predisposition to cancer in order to familiarise practising oncologists, geneticists and other professionals interested in cancer with this new and expanding field. The coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the detection and cloning of predisposition genes to a consideration of familial cancer syndromes, encompassing rare and common cancers. The text also includes a discussion of genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. To reflect the rapid advances in the field since the first edition, the contents have been thoroughly updated with new chapters on the biological basis of cancer predisposition, population-based studies of susceptibility, Von Hippel-Lindau syndrome and evaluation of management strategies for individuals at increased cancer risk.

Full Product Details

Author:   Ros Eng (Cancer Genetics Clinic, Institute of Cancer Research & Royal Marsden NHS Trust, Sutton, Surrey, UK) ,  Douglas Easton (University of Cambridge, UK) ,  Bruce Ponder ,  Charis Eng
Publisher:   Taylor & Francis Ltd
Imprint:   Hodder Arnold
Edition:   2nd New edition
Dimensions:   Width: 20.20cm , Height: 2.80cm , Length: 27.00cm
Weight:   1.383kg
ISBN:  

9780340762547

ISBN 10:   0340762543
Pages:   466
Publication Date:   27 August 2004
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Part One: Basic Principles 1. Genetic predisposition to cancer: an introduction 2. Biological basis of cancer predisposition 3. From families to chromosomes: genetic linkage and association studies for finding cancer–predisposition genes 4. From chromosomes to genes: how to isolate cancer-predisposition genes 5. Screening for mutations in cancer predisposition genes Part Two: Inherited Cancer Syndromes 6. Retinoblastoma: the paradigm for a genetically inherited cancer syndrome 7. Neurofibromatosis types 1 and 2 8. Multiple endocrine neoplasia type 2 9. Wilms tumour and other childhood renal tumours 10. Genetic susceptibility to renal cell carcinoma 11. The Li-Fraumeni syndrome and the role of TP53 mutations in cancer predisposition 12. Cowden syndrome Part Three: Chromosome Fragility Syndromes and the Gorlin Syndrome 13. Malignant disease and variations in radiosensitivity in ataxia telangiectasia patients 14. Fanconi anaemia 15. The Gorlin (Nevoid basal cell carcinoma) Syndrome 16. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer Part Four: The Common Cancers 17. Genetics and the common cancers 18. Familial Breast Cancer 19. The BRCA1 and BRCA2 genes 20. Screening for breast cancer in high-risk populations 21. The controversy of prophylactic mastectomy 22. The role of chemoprevention in the common cancers 23. Familial ovarian cancer 24. Familial colon cancer syndromes and their genetics 25. Screening and management of familial colon cancer 26. Familial prostate cancer and its management 27. Familial melanoma and its management 28. Familial predisposition to lung cancer 29. Genetic susceptibility to carcinoma of the head and neck, stomach, pancreas and the MEN 1 syndrome Part Five: Psychosocial, Ethical and Organisational Issues 30. The cancer family clinic 31. Psychological issues in cancer genetics 32. Ethical and insurance issues of testing for cancer-predisposition genes

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Author Information

Rosalind A. Eeles is Clinical Senior Lecturer and Honorary Consultant in Cancer Genetics and Clinical Oncology; Team Leader, Translation Cancer Genetics Team, Institute of Cancer Research; and Head, Cancer Genetics Unit, Royal Marsden NHS Trust, Sutton, UK Douglas F. Easton is Director, Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK Bruce A. J. Ponder is Cancer Research UK Professor of Oncology; Director, Cancer Research UK Human Genetics Research Group; and Co-Director, Hutchison-MRC Research Centre and Strangeways Laboratory for Genetic Epidemiology, University of Cambridge, UK Charis Eng is Dorothy E. Klotz Chair of Cancer Research; William C. and Joan E. Davis Professor of Cancer Research; Professor & Director, Division of Human Genetics, Department of Internal Medicine; and Director, Clinical Cancer Genetics Program, The Ohio State University, Columbus, Ohio, USA

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