An Innovative Approach to Understanding and Treating Cancer: Targeting pH: From Etiopathogenesis to New Therapeutic Avenues

Author:   Tomas Koltai (Former Medical Director, Hospital del Centro Gallego de Buenos Aires, Argentina) ,  Stephan J. Reshkin (Associate Professor, Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Italy) ,  Salvador Harguindey (Director, Institute for Clinical Biology and Metabolism, Vitoria, Spain)
Publisher:   Elsevier Science Publishing Co Inc
ISBN:  

9780128190593


Pages:   574
Publication Date:   17 January 2020
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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An Innovative Approach to Understanding and Treating Cancer: Targeting pH: From Etiopathogenesis to New Therapeutic Avenues


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Overview

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment.

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Author:   Tomas Koltai (Former Medical Director, Hospital del Centro Gallego de Buenos Aires, Argentina) ,  Stephan J. Reshkin (Associate Professor, Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Italy) ,  Salvador Harguindey (Director, Institute for Clinical Biology and Metabolism, Vitoria, Spain)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   1.060kg
ISBN:  

9780128190593


ISBN 10:   0128190590
Pages:   574
Publication Date:   17 January 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

PART 1: Metabolism and pH physiopathology of cancer 1. Introduction 2. Cancer metabolism 3. The pH alterations in cancer: causes and consequences 4. Lactic acid and its transport system 5. The sodium hydrogen exchanger 6. The voltage gated sodium channels 7. Carbonic anhydrases 8. Proton pumps 9. The sodium/bicarbonate co-transporter 10. Aquaporins 11. Invadopodia and the migration/invasion process 12. The Sp1 transcription factor PART 1: Therapeutics 13. Pharmacological interventions – Part I 14. Pharmacological interventions – Part II 15. Pharmacological interventions – Part III 16. Pharmacological interventions – Part IV 17. Therapeutics: the scheme 18. Therapeutics: ancillary treatments 19. Preventing metastasis 20. Proton inhibitors in pets’ cancer 21. pH-related nanoparticles in cancer treatment 22. Conclusions and future perspectives

Reviews

"""This book is a useful and thought-provoking review of some unique aspects of cancer growth and metabolism.  It is easy to follow and has many associated illustrations, tables, and text structures that aid in the review. It provides a good foundation to further investigate pH effects on malignancy, though the text would benefit from further updates and revision as these rapidly growing research fields progress."" --Doody"


This book is a useful and thought-provoking review of some unique aspects of cancer growth and metabolism. It is easy to follow and has many associated illustrations, tables, and text structures that aid in the review. It provides a good foundation to further investigate pH effects on malignancy, though the text would benefit from further updates and revision as these rapidly growing research fields progress. --Doody


Author Information

Tomas Koltai is Board Certified Specialist in Medical Oncology (1985), PhD in Chemistry (1997) and Master’s in Sciences in Molecular Oncology, University of Buenos Aires (2011). He has vast experience on cancer treatment at several positions: staff oncologist, Sanatorio Mater Dei, Argentina (1985-1990); Head of Oncology, Central Hospital of the Centro Gallego de Buenos Aires (1990-2000) and Medical Director, at the same institution (2000-2002); Head of the Department of Chemotherapy, National Social Services for Retirees, Argentina (2002-2014); Head of the Department of Oncology, Social Services of the National Food Workers Union, Argentina (2010-2014) and Medical Director at the same institution (2014-2016). He has authored several seminal publications on cancer and created the new “triple-edged cancer treatment”. Stephan Reshkin, PhD, is molecular biologist and Associate Professor at the University of Bari (Italy). Dr. Reshkin has published 108 scientific papers, several book chapters and co-authored An Innovative Approach to Understanding and Treating Cancer: Targeting pH (Elsevier, 2020). His main research interests are cancer cell and pancreatic ductal adenocarcinoma. Specialty in Medical Endocrinology, Royal Infirmary Hospital, University of Edinburgh, Scotland (1974-1977) and Department of Endocrinology, Eugene Taldmage Memorial Hospital, USA (1977-1981). Specialty in Medical Oncology, Roswell Park Memorial Institute, USA (1981-1985). Consultant in Medical Oncologist, University Clinic, Spain ( 1985-2000). He co-founded and was Vice-president of the International Society for Proton Dynamics of Cancer (ISPDC) (2008). Co-editor and author on a special issue in Seminars in Cancer Biology (2017) entitled “The new pH-centric anticancer paradigm in Oncology and Medicine”. Harguindey has published more than 140 scientific publications on a new and integral approach to the understanding of cancer and neurodegenerative diseases based upon hydrogen ion dynamics, from etiopathogenesis to treatment, that he originally and singlehandedly created.

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