Overview

Metabolic syndrome is no longer a simple cluster of risk factors. It is one of the defining medical challenges of modern life, linking central obesity, insulin resistance, dyslipidemia, hypertension, fatty liver disease, chronic kidney disease, cardiovascular disease, sleep disorders, reproductive complications, and cancer risk into one complex clinical picture. Textbook of Metabolic Syndrome: An Integrated Framework for Pathophysiology, Clinical Care, and Population Health offers a comprehensive, clinically grounded guide to understanding and managing this rapidly evolving field. Written for medical professionals, students, researchers, and public health thinkers, this textbook connects the biological foundations of metabolic disease with real-world diagnosis, treatment, prevention, and long-term care. Inside, readers will explore the evolution of metabolic syndrome, global and regional disease patterns, genetic and developmental origins, nutrition and physical activity, sleep and social determinants, adipose tissue biology, insulin resistance, beta-cell failure, chronic inflammation, the gut-liver-brain axis, and the expanding cardiorenal-metabolic framework. The book also examines major clinical complications, including type 2 diabetes, dyslipidemia, hypertension, MASLD, chronic kidney disease, reproductive and endocrine disorders, sleep apnea, musculoskeletal burden, and obesity-related cancers. Contemporary treatment chapters cover lifestyle intervention, behavioral therapy, digital health tools, GLP-1 receptor agonists, dual incretin therapies, SGLT2 inhibitors, finerenone, resmetirom, bariatric and metabolic surgery, pediatric management, and population-level prevention. Clear, detailed, and evidence-informed, this textbook gives readers a modern framework for seeing metabolic syndrome not as isolated numbers on a chart, but as an interconnected disease process requiring integrated clinical and public health action. For anyone seeking a deeper, practical, and current understanding of cardiometabolic medicine, this is an essential reference.

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