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P n, h t, r dn , nd w ll ng (d l r, l r, rub r, tum r) r th l m n f t t n f the nfl mm t r r . Abn rm l t f th joints f th spine, t d mu l , t nd n , l g m nt nd b n tru tur l bn rm l t can ll r ult n n and n d f r n ur urg l n ult t n . T ll , t nt w ll n t requ r immediate surgical nt rv nt n, and th r f r require tr tm nt t r du pain nd nh n qu l t of l f t v t . In m t , th genesis of n nfl mm t r , r g rdl f th t l g . W th th elucidation of th r l of nfl mm t r t k n , th r n w a l r und r t nd ng f th thw b wh h m n nt - nfl mm t r drug n ll v t nfl mm t n nd r l v pain. Th u f n n- t r d l nt - nfl mm t r drug (NSAID) m d t n t ll th m n t f m t l ll t ught l n n f r joint nd n r l t d nfl mm t r n, d t th r mm nl kn wn d ff t . NSAID m h n m r r m r l through nt r t n w th r nfl mm t r t k n interleukin (IL)-1 , IL-1b, IL-6 nd tum r n r factor (TNF- ). In r d n ntr t n f TNF- r b l v d t u th rd n l gn f nfl mm t n t ur.

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