Overview

This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

Full Product Details

Author:   Peter E. Angel ,  Peter Herrlich ,  Peter Herrlich ,  Alfred Nordheim
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.594kg
ISBN:  

9781138562165

ISBN 10:   1138562165
Pages:   322
Publication Date:   23 May 2019
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Table of Contents Characteristics of AP-1 Subunits Jun Family, Angel and Herrlich FOS Family, Schuermann Regulation of AP-1 Activity and Synthesis Protein/Protein Interactions: Factors Modulating AP-1 Activity, Sassone-Corsi Steroid Hormone Receptors/AP-1, Cato Post-Translational Modification: Jun Modification, Sachsenmaier and Radler-Pohl FOS Modification, Shaw Nuclear Uptake, Jeanteur Promoter Regulation: C-FOS, Nordheim C-Jun, Mechta and Yaniv Functions in Physiological Processe AP-1 Regulated Target Genes, Busslinger Neural Cell Function, Sassone-Corsi Differentiation, Rather Stress Response, Rahmsdorf Functions in Pathology FOS and Jun Oncogenes: FOS in Transformation, Miller Jun in Transformation, Vogt Oncogenes Acting through FOS and Jun: Raf Kinase, Rapp Other Oncogenes, Schanthal Adenovirus E1A/AP-1 Connection, van Dam and van der Eb Tumor Promotion and Carcinogenesis, Yuspa Tumor Progression, Hart

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