Overview
“Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”
Full Product Details
Author: Tamas Fulop ,
Claudio Franceschi ,
Katsuiki Hirokawa ,
Graham Pawelec
Publisher: Springer-Verlag New York Inc.
Imprint: Springer-Verlag New York Inc.
Edition: 2009 ed.
Dimensions:
Width: 15.50cm
, Height: 7.40cm
, Length: 23.50cm
Weight: 2.902kg
ISBN: 9781402090622
ISBN 10: 1402090625
Pages: 1693
Publication Date: 25 February 2009
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: In Print
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Reviews
From the reviews: The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections ... . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library. (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)
From the reviews: The Handbook on Immunosenescence, a 1,650-page 2-volume encyclopedia on aging research with 78 articles, includes 5 sections ! . Its strength is the broad coverage of aging, the immune system, and diseases of the elderly. For this reason, the Handbook on Immunosenescence is a worthy addition to any medical library. (Marc E. Weksler, Gerontology, Vol. 56 (3), March, 2010)
