Overview

Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage,' and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage- ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect of fibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy- matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts.

Full Product Details

Author:   G. Schlag ,  H. Redl
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1986
Dimensions:   Width: 17.00cm , Height: 0.90cm , Length: 24.40cm
Weight:   0.400kg
ISBN:  

9783540167341

ISBN 10:   354016734
Pages:   163
Publication Date:   01 August 1986
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

I. Principles of Fibrin Sealing.- The Importance of Fibrin in Wound Repair.- Fibrin Sealant and Its Modes of Application.- Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations.- Lysis and Absorption of Fibrin Sealant (Tissucol/Tisseel) (In Vitro and in Vivo Experiments).- Preliminary Results of a Randomized Controlled Study on the Risk of Hepatitis Transmission of a Two-Component Fibrin Sealant (Tissucol/Tisseel).- II. Otorhinolaryngology.- Remarks on a Daily Use of Tissucol (Tisseel) during 5 Years in Otology and Otoneurosurgery.- Selected Aspects of ENT Surgery in Central Midfacial Lesions.- Use of Fibrin Glue in Otorhinolaryngology.- Endoscopic Lateral Cordopexy.- The Use of Fibrin Sealant in Ear, Nose and Throat Surgery.- The Use of Fibrin Glue in Tympanoplasty.- Tissucol (Tisseel) in Tympanoplasty: Personal Observations.- The Use of Fibrin Sealant in Middle Ear Surgery and in Otoneurosurgery.- Simplified Application of Fibrinous Glue in Middle-Ear Surgery.- A New Application Method for Fibrin Sealant: The Glue Gun.- Fibrin Sealant (Tissucol/Tisseel) in Ear Surgery (A 4-Year Experience).- En Bloc Ethmoidectomy Through the Combined Craniofacial Approach: Surgical Technique.- Local Application of Human Fibrin Seal (Tissucol/Tisseel) in Tonsillectomies and Adenectomies in Patients with Bleeding Disorders. Ten Years' Clinical Experience.- The Use of Fibrin Glue in Auricular Surgery.- Reconstruction of the Open Mastoidectomized Ear: Two Surgical Techniques.- Fibrinogen Glue in Reconstructive Surgery of the Skull Base.

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