Overview

Nearly 50 investigators of clinical trials of myocardial infarction (MI) therapy explain how their work has contributed to the late-1990s standard of care. This work examines clinical trials that have established the efficacy of particular therapies, including acute coronary reperfusion, the use of aspirin, beta-blockers, ACE inhibitors and the reduction of blood cholesterol; reviews trials that have cast doubt on the efficacy of other therapies, including the early and late use of calcium channel blockers, and the routine use of haparin, nitroglycerin and magnesium; and deals with alternative onerall strategies for MI care, such as invasive versus conservative management and the interplay of thrombolysis and PTCA.

Full Product Details

Author:   Valentin Fuster (Mt. Sinai School of Medicine, New York, New York, USA) ,  Valentin Fuster
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 21.60cm , Height: 3.00cm , Length: 27.90cm
Weight:   1.089kg
ISBN:  

9780824719326

ISBN 10:   0824719328
Pages:   520
Publication Date:   16 February 1999
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

THERAPIES WITH ESTABLISHED EFFICACY Thrombolysis GISSI-1, Gianni Tognoni and Aldo P. Maggioni ISIS-2, Peter Sleight ASSET, Robert G. Wilcox ISIS-3, Peter Sleight GUSTO-1, Maran Thamilarasan and Eric J. Topol LATE, John R. Hampton EMERAS, Ernesto Paolasso and Rafael Diaz Insights from the GUSTO Trials on Studies of Coronary Reperfusion, Robert M. Califf Primary PTCA The Mayo Clinic Primary PTCA Trial, David R. Holmes, Jr., and R. J. Gibbons The Zwolle Primary PTCA Trial, Felix Zijlstra GUSTO-IIB, Neeraj Jolly and Stephen G. Ellis Aspirin ISIS-2, Peter Sleight Beta-Blockers: Early Use ISIS-1, Peter Sleight The Goeteborg Metoprolol Trial, Ake Hjalmarson MIAMI, Ake Hjalmarson TIMI-IIB, Robert Roberts and Eugene Braunwald Beta-Blockers: Delayed Use The Norwegian Timolol Study, Terje R. Pederson BHAT, Robert P. Byington ACE Inhibitors: Early Use CONSENSUS-II, John Kjekshus, Karl Swedberg, and Steven M. Snappin GISSI-3, Gianni Tognoni and Aldo P. Maggioni ISIS-4, Peter Sleight SMILE, Claudio Borghi and Ettore Ambrosini ACE Inhibitors: Delayed Use SAVE, Marc A. Pfeffer and Eugene Braunwald AIRE, Alistair S. Hall and Stephen G. Ball TRACE, Lars Kober and Christian Torp-Pedersen Cholesterol Reduction CARE, David T. Nash THERAPIES WITHOUT ESTABLISHED EFFICACY Calcium Channel Blockers: Early Use DAVIT-1, Jorgen Fischer Hansen TRENT, Robert G. Wilcox Calcium Channel Blockers: Delayed Use MDPIT, Robert E. Goldstein SPRINT, Solomon Behar DAVIT-2, Jorgen Fischer Hansen Heparin GISSI-2, Gianni Tognoni and Aldo P. Maggioni ISIS-3, Peter Sleight Nitrates GISSI3, Gianni Tognoni and Aldo P. Maggioni ISIS-4, Peter Sleight Magnesium LIMIT-2, Kent L. Woods ISIS-4, Peter Sleights ALTERNATIVE STRATEGIES IN ACUTE MYOCARDIAL INFARCTION Invasive or Conservative Management TIMI-IIB, Christopher P. Cannon and Eugene Braunwald SWIFT, David P. de Bono Thrombolysis and PTCA TIMI-IIA, Robert P. Giugliano and Eugene Braunwald TAMI and PAMI, William W. O'Neill

Reviews

From the Foreword Cardiologists, and when necessary general physicians, have now an arsenal of weapons to combat myocardial infarction. This volume is a visit to that arsenal: to my knowledge, there is no other volume where one could find so readily accessible all the information concerning the many interventions that are available today. Clinical trials are described, explained and evaluated, thus giving the physician the ability to apply effectively the remarkable knowledge that is available. Much credit must be given to the editors and the many contributors for providing the medical community with such a lucid and helpful review. Claude Lenfant, M.D. Bethesda, Maryland ...a very comprehensive and lucid review of myocardial infarction trials and...highly recommended for all those caring for patients with myocardial infarction. -Acta Cardiologica

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