Overview

In the years following publication of the DSM-5 (R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5 (R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Full Product Details

Author:   Dennis S. Charney (Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai) ,  Eric J. Nestler (Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai) ,  Pamela Sklar (Chief of the Division of Psychiatric Genomics; Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai) ,  Joseph D. Buxbaum (Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences; Director of the Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai)
Publisher:   Oxford University Press Inc
Imprint:   Oxford University Press Inc
Edition:   5th Revised edition
Dimensions:   Width: 22.40cm , Height: 4.60cm , Length: 28.40cm
Weight:   3.002kg
ISBN:  

9780190681425

ISBN 10:   019068142
Pages:   1024
Publication Date:   11 January 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

Section 1: Emerging and Established Technologies 1. Genetic Methodologies and Applications Shaun M. Purcell 2. Network Methods for Elucidating the Complexity of Common Human Diseases Eric E. Schadt 3. The Human Brain and its Epigenome Andrew Chess and Schahram Akbarian 4. Methods for In Vivo Gene Manipulation Lisa M. Monteggia and Wei Xu 5. Application of Stem Cells to Understanding Psychiatric Disorders Zijia Zhang and Kristen Brennand 6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges Lief E. Fenno and Karl Deisseroth 7. In Vivo Circuit Analysis Ryan Bowman, Hannah Schwennsen, Kafui Dzirasa, and Rainbo Hultman 8. Magnetic Resonance Methodologies Peter A. Bandettini and Hanzhang Lu 9. PET Brain Imaging Methodologies Ansel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson 10. Neuromodulation and Psychiatric Disorders Wayne K. Goodman and Mark S. George 11. The Neurobiology of Sleep Giulio Tononi and Chiara Cirelli Section 2: Psychotic Disorders 12. Diagnosis and Epidemiology of Psychotic Disorders Emma Meyer, Julie Walsh-Messinger, and Dolores Malaspina 13. Genetics of Schizophrenia and Bipolar Disorder Pamela Sklar 14. Neuroimaging of Psychotic Disorders Stephan Heckers, Neil Woodward, and Dost OEngur 15. Animal and Cellular Models of Psychotic Disorders Mikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross 16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies Jared Young, Alan Anticevic, and Deanna M. Barch 17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies Seth G. N. Grant 18. Cellular Mechanisms of Psychotic Disorders: Human Studies Samuel J. Dienel and David A. Lewis 19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa 20. The Neurobiology and Treatment of Bipolar Disorder Katherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis 21. Novel Approaches for Treating Psychotic Disorders Tiago Reis Marques and Shitij Kapur 22. Current Treatments for Psychotic Disorders Deepak K. Sarpal and Anil K. Malhotra Section 3: Depression 23. Diagnosis and Epidemiology of Depression Nicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough 24. Genetics of Depression Douglas F. Levinson and Walter E. Nichols 25. Neuroimaging of Depression Michele A. Bertocci and Mary L. Phillips 26. Animal Models of Mood Disorders Lyonna F. Alcantara, Eric M. Parise, and Carlos A. Bolanos-Guzman 27. Neurotrophic Mechanisms of Depression: Animal and Human Studies Ronald S. Duman 28. Immune Mechanisms of Depression Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, and Scott J. Russo 29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical Evidence Jill M. Goldstein, L Holsen, S Cherkerzian, M Misra, and RJ Handra 30. New Approaches for Treating Depression Eric J. Nestler 31. Current Treatments for Depression John H. Krystal and Dennis S. Charney Section 4: Anxiety Disorders 32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive and Trauma- and Stressor-Related Disorders Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne 33. Genetics of Anxiety Disorders Takeshi Otowa, Roxann Roberson-Nay, Mandy Bekhbat, Gretchen N. Neigh, and John M. Hettema 34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders Madeleine S. Goodkind and Amit Etkin 35. Animal Models and Assays Probing anxiety Related Behaviors and Neural Circuits Ramon Tasan and Nicholas Singewald 36. Distinct Neural Mechanisms Underlying Fear and Anxiety Joseph LeDoux 37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human Studies Anfei Li, Francis S. Lee 38. The Neurobiology of Resilience Adriana Feder, Sarah R. Horn, Margaret Haglund, Steven M. Southwick, and Dennis S. Charney 39. Novel Approaches for Treating Anxiety Disorders David A. Sturman,Milissa L. Kaufman, Cara E. Bigony, and Kerry J. Ressler 40. Novel treatment approaches for anxiety disorders Adam J. Guastella, Alice Norton, Gail A. Alvares, and Christine Song Section 5: Substance Use Disorders 41. Epidemiology of Substance Use Disorders Denise B. Kandel, Mei-Chen Hu, Pamela C. Griesler, Bradley T. Kerridge, and Bridget F. Grant 42. The Genetic Basis of Addictive Disorders David Goldman, Zhifeng Zhou, and Colin Hodgkinson 43. Animal Models of Addiction Christopher Evans J., Brigitte L. Lieffer, David Jentsch, and Rafael J. Maldonado 44. Reward Circuitry and Drug Addiction Vaughn R. Steele, Vani Pariyadath, Rita Z. Goldstein, and Elliot A. Stein 45. Molecular Neuroimaging in Addictive Disorders Edythe D. London and Chelsea L. Robertson 46. Cellular and Molecular Mechanisms of Addiction Kathryn J. Reissner and Peter W. Kalivas 47. Brain Development and the Risk for Substance Abuse Mary M. Heitzeg and B.J. Casey 48. Pharmacotherapy of Substance Use Disorders Jane B. Acri and Phil Skolnick 49. Current Approved Pharmacotherapies for Substance Use Disorders Alexis S. Hammond and Eric C. Strain Section 6: Dementia 50. Diagnosis and Epidemiology of Dementia William C. Kreisl and Christiane Reitz 51. Genetics of Dementia Alan E. Renton and Alison M. Goate 52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Brian A. Gordon, Stephanie J.B. Vos, and Anne M. Fagan 53. Animal Models of Alzheimer's Disease David Morgan 54. Cellular Mechanisms of Dementia: Animal and Human Studies Li Gan 55. Neurobiology of Lewy Body Dementias: Animal and Human Studies James E. Galvin and Jose Tomas Bras 56. Neurobiology of FTD: Animal and Human Studies Dah-eun Chloe Chung, Jeannette N. Stankowski, and Leonard Petrucelli 57. Current Treatments for Alzheimer's Disease Mary Sano and Judith Neugroschil Section 7: Psychiatric Disorders of Childhood Onset 58. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders of Childhood Elise Robinson, Benjamin Neale, and Mark Daly 59. Genetics of Pediatric Psychiatric Disorders Silvia de Rubeis, M. Pilar Trelles, and Joseph D. Buxbaum 60. Neuroimaging in Pediatric Psychiatric Disorder Timothy P.L. Roberts and Luke Bloy 61. Animal and Cellular Models of Pediatric Psychiatric Disorders Elodie Drapeau, Hala Harony-Nicolas, and Jacqueline N. Crawley 62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human Studies Silvia De Rubeis, Kathryn Roeder, and Bernie Devlin 63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human Studies Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick Hof, Joseph D. Buxbaum, and Alexander Kolezvon 64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies Stephen V. Faraone, Pradeep G. Bhide, and Joseph Biederman 65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Human and Animal Studies Christopher Pittenger 66. Neurobiology of Eating Disorders: Animal and Human Studies Thomas Hildebrandt and Ashley Heywood 67. Novel Approaches for Treating Pediatric Psychiatric Disorders Supritha Prasad and Edwin H. Cook, Jr. 68. Current Treatments for Pediatric Psychiatric Disorders M. Pilar Trelles, Paige Siper, and Dorothy Grice Section 8: Future of Psychiatric Diagnosis: Toward Precision Psychiatry 69. DSM-5 (R) Overview and Goals Darrel A. Regier, Sarah E. Morris, and Susan K. Schulz 70. The Present and Future of Psychiatric Diagnosis Steven E. Hyman 71. The NIMN Research Domain Criteria Project: Toward Precision Medicine in Psychiatry Bruce N. Cuthbert 72. Computational Psychiatry and the Bayesian Brain Karl J. Friston and Raymond J. Dolan

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Dennis S. Charney, MD Anne and Joel Ehrenkranz, Dean, Icahn School of Medicine at Mount Sinai President for Academic Affairs Mount Sinai Health System Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences New York, NY Joseph D. Buxbaum, PhD G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences Deputy chair, department of psychiatry Director, Seaver Autism Center for research and treatment Icahn School of Medicine at Mount Sinai New York, NY Pamela Sklar, MD, PhD Mount Sinai professor of Psychiatric genomics Chair, department of Genetics and Genomic Sciences Professor, Departments of Genetics and Genomic Sciences, Psychiatry, Neuroscience, and Director, Center for Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York, NY Eric J. Nestler, MD, PhD Nash Family Professor Departments of Neuroscience and Psychiatry Director, The Friedman Brain Institute Dean for academic and scientific affairs Icahn School of Medicine at Mount Sinai New York, NY

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