Overview

Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration. The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering. The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.

Full Product Details

Author:   Joao F. Mano (University of Minho,Caldas das Taipas, Portugal)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-VCH Verlag GmbH
ISBN:  

9783527652303

ISBN 10:   3527652302
Pages:   606
Publication Date:   11 February 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Electronic book text
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

PREFACE PART I: Examples of Natural and Nature-Inspired Materials BIOMATERIALS FROM MARINE-ORIGIN BIOPOLYMERS Taking Inspiration from the Sea Marine-Origin Biopolymers Marine-Based Tissue Engineering Approaches Conclusions HYDROGELS FROM PROTEIN ENGINEERING Introduction Principles of Protein Engineering Structural Diversity and Applications of Protein-Engineered Hydrogels Development of Biomimetic Protein-Engineered Hydrogels for Tissue Engineering Applications Conclusions and Future Perspective COLLAGEN-BASED BIOMATERIALS FOR REGENERATIVE MEDICINE Introduction Collagens In Vivo Collagen In Vitro Collagen Hydrogels Collagen Sponges Multichannel Collagen Scaffolds What Tissues Do Collagen Biomaterials Mimic? (see Table 3.1) Concluding Remarks SILK-BASED BIOMATERIALS Introduction Silk Proteins Mechanical Properties Biomedical Applications of Silk Final Remarks ELASTINLIKE MACROMOLECULES General Introduction Materials Engineering - an Overview on Synthetic and Natural Biomaterials Elastin as a Source of Inspiration for Nature-Inspired Polymers Nature-Inspired Biosynthetic Elastins ELRs as Advanced Materials for Biomedical Applications Conclusions BIOMIMETIC MOLECULAR RECOGNITION ELEMENTS FOR CHEMICAL SENSING Introduction Theory of Molecular Recognition Molecularly Imprinted Polymers Supramolecular Chemistry 5 Biomolecular Materials Summary and Future of Biomimetic-Sensor-Coating Materials PART II: Surfaces Aspects BIOLOGY LESSONS FOR ENGINEERING SURFACES FOR CONTROLLING CELL- MATERIAL ADHESION Introduction The Extracellular Matrix Protein Structure Basics of Protein Adsorption Kinetics of Protein Adsorption Cell Communication Cell Adhesion Background Integrins and Adhesive Force Generation Overview Adhesive Interactions in Cell, and Host Responses to Biomaterials Model Systems for Controlling Integrin-Mediated Cell Adhesion Self-Assembling Monolayers (SAMs) Real-World Materials for Medical Applications Bio-Inspired, Adhesive Materials: New Routes to Promote Tissue Repair and Regeneration Dynamic Biomaterials FIBRONECTIN FIBRILLOGENESIS AT THE CELL- MATERIAL INTERFACE Introduction Cell-Driven Fibronectin Fibrillogenesis Cell-Free Assembly of Fibronectin Fibrils Material-Driven Fibronectin Fibrillogenesis NANOSCALE CONTROL OF CELL BEHAVIOR IN BIOINTERFACES Nanoscale Cues in Cell Environment Biomimetics of Cell Environment Using Interfaces Cell Responses to Nanostructured Materials The Road Ahead SURFACES WITH EXTREME WETTABILITY RANGES FOR BIOMEDICAL APPLICATIONS Superhydrophobic Surfaces in Nature Theory of Surface Wettability Fabrication of Extreme Water-Repellent Surfaces Inspired by Nature Applications of Surfaces with Extreme Wettability Ranges in the Biomedical Field Conclusions BIO-INSPIRED REVERSIBLE ADHESIVES FOR DRY AND WET CONDITIONS Introduction Gecko-Like Dry Adhesives Bioinspired Adhesives for Wet Conditions The Future of Bio-Inspired Reversible Adhesives LESSONS FROM SEA ORGANISMS TO PRODUCE NEW BIOMEDICAL ADHESIVES Introduction Composition of Natural Adhesives Recombinant Adhesive Proteins Production of Bio-Inspired Synthetic Adhesive Polymers Perspectives PART III: Hard and Mineralized Systems INTERFACIAL FORCES AND INTERFACES IN HARD BIOMATERIAL MECHANICS Introduction Hard Biological Materials Bioengineering and Biomimetics Summary NACRE-INSPIRED BIOMATERIALS Introduction Structure of Nacre Why Is Nacre So Strong? Strategies to Produce Nacre-Inspired Biomaterials Conclusions SURFACES INDUCING BIOMINERALIZATION Mineralized Structures in Nature: the Example of Bone Learning from Nature to the Research Laboratory Smart Mineralizing Surfaces In Situ Self-Assembly on Implant Surfaces to Direct Mineralization Conclusions BIOACTIVE NANOCOMPOSITES CONTAINING SILICATE PHASES FOR BONE REPLACEMENT AND REGENERATION Introduction Nanostructure and Nanofeatures of the Bone Nanocomposites-Containing Silicate Nanophases Final Considerations PART IV: Systems for the Delivery of Bioactive Agents BIOMIMETIC NANOSTRUCTURED APATITIC MATRICES FOR DRUG DELIVERY Introduction Biomimetic Apatite Nanocrystals Biomedical Applications of Biomimetic Nanostructured Apatites Biomimetic Nanostructured Apatite as Drug Delivery System Adsorption and Release of Proteins Conclusions and Perspectives NANOSTRUCTURES AND NANOSTRUCTURED NETWORKS FOR SMART DRUG DELIVERY Introduction Stimuli and Sensitive Materials Stimuli-Responsive Nanostructures and Nanostructured Networks Concluding Remarks PROGRESS IN DENDRIMER-BASED NANOCARRIERS Fundamentals Applications of Dendrimer-Based Polymers Final Remarks PART V: Lessons from Nature in Regenerative Medicine TISSUE ANALOGS BY THE ASSEMBLY OF ENGINEERED HYDROGEL BLOCKS Introduction Tissue/Organ Heterogeneity In Vivo Assembly of Engineered Hydrogel Blocks Conclusions INJECTABLE IN-SITU-FORMING SCAFFOLDS FOR TISSUE ENGINEERING Introduction Injectable In-Situ-Forming Scaffolds Formed by Electrostatic Interactions Injectable In-Situ-Forming Scaffolds Formed by Hydrophobic Interactions Immune Response of Injectable In-Situ-Forming Scaffolds Injectable In-Situ-Forming Scaffolds for Preclinical Regenerative Medicine Conclusions and Outlook BIOMIMETIC HYDROGELS FOR REGENERATIVE MEDICINE Introduction Natural and Synthetic Hydrogels Hydrogel Properties Engineering Strategies for Hydrogel Development Applications in Biomedicine BIO-INSPIRED 3D ENVIRONMENTS FOR CARTILAGE ENGINEERING Articular Cartilage Histology Spontaneous and Forced Regeneration in Articular Cartilage What Can Tissue Engineering Do for Articular Cartilage Regeneration? Cell Sources for Cartilage Engineering The Role and Requirements of the Scaffolding Material Growth Factor Delivery In Vivo Conclusions SOFT CONSTRUCTS FOR SKIN TISSUE ENGINEERING Introduction Structure of Skin Current Biomaterials in Wound Healing Wound Dressings and Their Properties Biomimetic Approaches in Skin Tissue Engineering Final Remarks

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Author Information

Jo?o F. Mano (CEng, PhD, DSc) is an Associate Professor at the Polymer Engineering Department, University of Minho, Portugal, and principal investigator at the 3B's research group - Biomaterials, Biodegradables and Biomimetics. He is the former director of the Master's Program in Biomedical Engineering at the University of Minho. His current research interests include the development of new materials and concepts for biomedical applications, especially aimed at being used in tissue engineering and in drug delivery systems. In particular, he has been developing biomaterials and surfaces that can react to external stimuli, or biomimetic and nanotechnology approaches to be used in the biomedical area. J.F. Mano authored more than 330 papers in international journals and three patents. He belongs to the editorial boards of 5 well-established international journals. J.F. Mano awarded the 'Stimulus to Excellence' by the Portuguese Minister for Science and Technology in 2005, the 'Materials Science and Technology Prize', attributed by the Federation of European Materials Societies in 2007 and the major 'BES innovation award' in 2010.

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