Overview

One of the most active areas in medicinal chemical research concerns the search for drugs used to treat different forms of cancer. This Handbook contains records for all the major drugs currently in use to treat cancer. Monographs are provided for 409 antineoplastic agents and, in addition, 23 cytoprotectant agents are described. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th Edition) Number are given. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

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G.W.A. Milne was a Senior Researcher at the National Institutes of Health in Bethesda, MD, USA for 35 years where he worked on the use of spectroscopy for structure determination of organic compounds, and on molecular modeling in the design of drugs for the treatment of cancer and AIDS. From 1980 until 1998 he worked in molecular modeling and information technology at the National Cancer Institute, one of the NIH Institutes. He has been active for many years in the fields of chemical information and chemical computation and is the Editor of the American Chemical Society's Journal of Chemical Information and Computer Science; Gardner's Chemical Synonyms and Trade Names, Eleventh Edition (Ashgate); and Drugs: Synonyms and Properties (Ashgate).

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