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Author:   Tomas Koltai, PhD. (Former Medical Director, Hospital del Centro Gallego de Buenos Aires, Argentina) ,  Larry Fliegel, PhD. (Professor Emeritus, Department of Biochemistry, Faculty of Medicine, University of Alberta, Canada)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   0.450kg
ISBN:  

9780443363108

ISBN 10:   0443363102
Pages:   1100
Publication Date:   26 June 2026
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
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Table of Contents

1. Introduction 2. Basics of oncological molecular biology 3. The Hanahan and Weinberg hallmarks of cancer 4. Biology of metastasis 5. Mitotic errors, mutations and DNA repair 6. Growth factors, their receptors and proliferative pathways 7. Angiogenesis 8. Hypoxia in cancer 9. The Unique Metabolism of Cancer Cells 10. Molecular mechanisms of action of chemotherapeutic drugs. Part I: targeting DNA and replication. Part II: targeted treatments. 11. ROS and cancer 12. Cancer immunology and its targeting 13. Cancer environment and Groucho Marx’s principles 14. Tumor heterogeneity a different way of looking at cancer 15. Resistance to treatment and multidrug resistance (MDR) 16. Pancreatic cancer resistance to treatment: a paradigm of chemoresistance 17. Cancer cachexia 18. Tumor markers 19. The origins and pathogenesis of cancer 20. Extracellular vesicles: Exosomes and microvesicles in cancer 21. Cancer stem cells 22. Repurposing drugs and nutraceuticals for cancer treatment 23. pH homeostasis and ion channels in cancer 24. The metabolic control center: a hub of normal and cancer cell survival 25. Tumor kinetics 26. The ubiquitin-proteasome pathway and cancer 27. RNA in cancer Part I: MicroRNAs MiRs or miRNAs Part II: Long non-coding RNA (lncRNA) Part III: RNA binding proteins (RBPs) 28. Cell migration in cancer Part I: mechanisms of migration and invasion Part II: Targeting cancer cell migration and invasion 29. Epigenetics and cancer 30. Peroxisome, peroxisome proliferators and peroxisome proliferator-activated receptors in cancer 31. Hormone-dependent cancer 32. Summary and final words

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Author Information

Tomas Koltai is Board Certified Specialist in Medical Oncology (1985), PhD in Chemistry (1997) and Master’s in Sciences in Molecular Oncology, University of Buenos Aires (2011). He has vast experience on cancer treatment at several positions: staff oncologist, Sanatorio Mater Dei, Argentina (1985-1990); Head of Oncology, Central Hospital of the Centro Gallego de Buenos Aires (1990-2000) and Medical Director, at the same institution (2000-2002); Head of the Department of Chemotherapy, National Social Services for Retirees, Argentina (2002-2014); Head of the Department of Oncology, Social Services of the National Food Workers Union, Argentina (2010-2014) and Medical Director at the same institution (2014-2016). He has authored several seminal publications on cancer and created the new “triple-edged cancer treatment”. Research in Dr. Fliegel’s laboratory investigates membrane proteins’ function, how intracellular pH is regulated and the role of Na+/H+ exchanger in human disease, especially heart disease and breast cancer. The work was funded by CIHR and other sources. Dr. Fliegel has published over 150 publications in numerous journals including J. Biological Chemistry, J. Molecular and Cellular Cardiology, Hypertension, Cancer Research, Basic Research in Cardiology and others. He has authored two books and served on several editorial boards of Journals and grant panels such as CIHR. His awards include a Killam Annual Professor Award (2009-10), a Tier one Basic Science Mentoring Award (2013), McCalla Research Professorship Award (2007) and Alberta Heritage Foundation for Medical Research Scientist Award (2006-2013).

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