Overview

This text contains a selection of lectures given during the 5th International Symposium on Adenosine and Adenine Nucleotides, recently held in Philadelphia, Pennsylvania. It covers a wide range of subjects from molecular and cellular biology to clinical applications. Emphasis has been placed on cutting edge information derived from studies using molecular and cellular biology techniques applied to the field of adenosine and adenine nucleotide research. The book also includes information on potentially promising developments in the therapeutic applications of adenosine related drugs and ATP. The tradition of past meetings is also maintained by including in the programme presentations of new research in the areas of purine metabolism and physiology, and pharmacology of adenosine and adenine nucleotides. This book should be an up-to-date reference book for basic and clinical scientists in the field of adenosine and adenine nucleotides.

Full Product Details

Author:   Luiz Belardinelli ,  A. Pelleg
Publisher:   Springer
Imprint:   Springer
Edition:   1995 ed.
Dimensions:   Width: 17.80cm , Height: 3.10cm , Length: 25.40cm
Weight:   2.640kg
ISBN:  

9780792331902

ISBN 10:   0792331907
Pages:   543
Publication Date:   31 March 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Molecular and Cellular Biology of Adenosine and ATP.- A. Molecular Biology.- 1. Molecular Biology of Adenosine Receptors.- 2. Recombinant Techniques as Applied to the Study of A1Adenosine Receptors.- 3. In Situ Hybridization of Adenosine Receptors in Brain.- 4. Molecular Modeling of Adenosine A1and A2aReceptors.- 5. Purinoceptor Nomenclature: Challenges for the Future.- 6. Molecular Cloning and Expression of SNST1, a Renal Sodium/Nucleoside Cotransporter.- 7. Antibodies as Probes of Nitrobenzylthioinosine-Sensitive Nucleoside Transporters.- B. Cellular Biology.- 8. Regulation of the Human A1Adenosine Receptor Gene.- 9. Adenosine A2Receptor Regulation of Striatal Gene Expression.- 10. Neuronal ATP Receptors.- 11. Possible Role of Glia in the Induction of CNS-like Properties in Aortic Endothelial Cells: ATP-Activated Channels.- 12. Modulation of Cardiomyocyte Membrane Currents by A1Adenosine Receptors.- 13. Regulation of Phospholipases C and D, Calcium, and Protein Kinase C by Adenosine A1Receptors.- 14. Adenosine Derived from Neurally Released ATP Is the Physiologic Cause of Skeletal Neuromuscular Depression.- 15. Adenosine 5’-Triphosphate Receptor—Mediated Currents in Rat Intracardiac Neurons.- 16. Desensitization of A1Adenosine Receptors.- II. Medicinal Chemistry.- 17. Selective A2Adenosine Receptor Agonists with Potent Inhibitory Activity on Platelet Aggregation.- 18. Novel ATP Agonists Reveal Receptor Heterogeneity within P2xand P2ySubtypes.- 19. Adenosine Receptors: Selective Agonists and Antagonists.- III. Purine Release and Metabolism.- 20. Cardiac Energetics and Adenosine Formation.- 21. Extracellular Hydrolysis of ATP and Formation of Adenosine in the Nervous System.- 22. P-Glycoprotein Serves as a Transporter of Cellular ATP.- 23. On the Origin ofExtracellular ATP in Cardiac Blood Vessels: A Dual Role for Endothelium.- 24. Aliosteric Modulation of Nucleoside Transport by Adenosine and ATP.- IV. Physiology and Pharmacology of Adenosine and ATP: Effects on Tissue and Organs.- A. Renal System.- 25. Chloride Secretion in the Shark Rectal Gland: A Model for Epithelial Adenosine Receptors.- B. Cardiovascular System.- 26. Myocardial Adenosine Receptors.- 27. Coronary Adenosine Receptors: Subtypes, Localization, and Function.- 28. Biologic Activity of Adenosine A2aReceptor Antagonists.- C. Nervous System (Central and Peripheral).- 29. Role of A2aReceptors in the Hippocampus and Motor Nerve Endings.- 30. Augmentation of Extracellular Adenosine Formation as a Potential Therapeutic Strategy for Preventing Excessive Excitatory Amino Acid Transmission in the Central Nervous System.- 31. Purinoceptors on Glial Cells of the Central Nervous System: Functional and Pathologic Implications.- 32. Inhibitory Action of Adenosine and Adenine Dinucleotides on Synaptic Transmission in the Central Nervous System.- 33. Receptors for ATP at Peripheral Neuroeffector Junctions.- 34. Anatomic-Functional Correlates of Adenosine-5’-Triphosphate Triggered Vagal Depressor Reflex.- 35. Excitatory Effect of Adenosine on Cardiac Sympathetic Afferent Fibers.- 36. Mechanism of Anginal Pain: The Key Role of Adenosine.- D. Other Systems.- 37. The P2ZReceptor and its Regulation of Macrophage Function.- 38. Effects of Purinoceptor Agonists on Insulin Secretion.- V. Cytoprotective Actions of Adenosine.- A. Cardioprotection.- 39. Receptor-Mediated and Metabolic Effects of Adenosine in Ischemic and Postischemic Myocardium.- 40. Role of Activation of Ecto-5’- Nucleotidase for Cardioprotection in Ischemic Preconditioning.- 41. Adenosine Uptake Blockersfor Cardioprotection.- 42. Endothelial Adenosine Receptors Modulate Leukocyte Adhesion: Relevance for Myocardial Reperfusion Damage.- B. Neuroprotection.- 43. Adenosine and Brain Ischemia.- 44. Adenosine Metabolites Are a Source of Oxygen Free Radicals in the Ischemic/Reperfused Rat Brain.- 45. Hyperglycemic Ischemia and Reperfusion: Effects on Adenosine and Adenine Nucleotides.- C. Renal Protection.- 46. Studies on the Mechanism by Which Adenosine Receptor Antagonists Attenuate Acute Renal Failure.- VI. Therapeutic Applications.- A. Cardiovascular.- 47. Clinical Electrophysiology of Adenosine.- 48. Myocardial Imaging during Adenosine Infusion.- 49. Intravenous Adenosine and Lidocaine in the Limitation of Infarct Size: Preliminary Safety Data.- 50. Role of Adenosine in the Phenomenon of Ischemic Preconditioning.- B. Nervous System.- 51. Anticonvulsant Actions of Novel and Reference Adenosine Agonists.- 52. Behavioral Effects of Adenosine Receptor Stimulation.- 53. Evidence for the Existence of Antagonistic Intramembrane Adenosine A2a/Dopamine D2Receptor Interactions in the Basal Ganglia: Analysis from the Network to the Molecular Level.- C. Other Applications.- 54. Role of Adenosine and Adenosine Triphosphate as Anesthetic Adjuvants.- 55. Mechanisms and Therapeutic Actions of Uridine Triphosphate in the Lung.

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